Fantastic Voyage
Rods and rings are mysterious subcellular structures identified just a few years ago by scientists studying how cells respond to antiviral drugs, such as those used against hepatitis C.
1 Color Coded
These are mouse embryonic fibroblasts stained for microtubules (turquoise), nuclei (orange), and rods and rings (light green).
2 Discovery
The rods and rings appear to contain enzymes that cells use for synthesizing DNA building blocks. Patients treated with some antiviral drugs develop antibodies against these enzymes.
3 Imaging
This image is a “z-stack projection” acquired using the Olympus FV1000 microscope in Emory’s Integrated Cellular Imaging Core.
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